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For the prolonged treatment of lupus or rheumatoid arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, the excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence.
Hydroxychloroquine can worsen existing cases of both psoriasis and porphyria. Many in the field of medical professions today are asking themself why this profession is not trustworthy anymore. Yes if I am in the acute stage caused by the COVID 19, my physician would proscribe me hydroxychloroquine even if I need to fight to get it.
It is worth also to point out that in the group of 14 patients treated with only Plaquenil HDC , 2 were asynptomatic, resulted positive the Day 0, and then on always negative. As possible false positive cases or at least anomalous cases, it would have been better not to include in the result analysis. I am not comfortable with 2 points of your article. Guit by association argument. The sexual harassment story and other arguments against the person of Raoult: argumentum ad hominem.
Maybe it was no clear what the last section of my article meant to convey. Raoult was guilty of covering up the sexual abuse by his subordinate group leader for 2 years. His only actions were to threaten and blackmail the victims, even to attempt sacking them. It fits to the overall pattern of Raoult being a bullying sadistic misogynous tyrant who created over many years an oppressive atmosphere of fear and deference at his institute of employees.
Every single case of such lab leadership worldwide resulted in massive research fraud, simply because group leaders, students and postdocs are afraid to contradict or to displease the boss. Hence it is important to know in which scientific work environment the chloroquine results were obtained. Like Liked by 4 people. Thanks Leonid for this useful piece of work — as always! I have also published a statement yesterday about that fraud affair and its extra-scientific consequences.
Of course, I will relay this English version as well and recommend your blog, which is really a great place to turn to for a better understanding of science at work. Oh, and by the way, do you allow me to use your illustrations pictures and graphics? They are kind of central to your demonstration.
But I still want to ask for your authorization. In this case, none of graphics are mine: they are actually links to original sources. I only hold copyright on my cartoons. He mainly talks about horizontal transfer which may differ from the non-specialist knowledge but is not in any case a refutation of evolution. At best a refutation of darwinian theory which is the current scientific consensus? Synthetic theory of evolution. He says recent discoveries in genetics show how frequently genes are exchanged not just between different microbial species but also between microbes and complex organisms, for instance, in the human gut.
And if you had covi19 Leonid or someone you love? What would you do? I also bet you will claim you would not. HCQ trials are going ahead, massive, so we will know in about 10 days. If Raoult was wrong, you can destroy him then. If Raoult is right what is the point really? Are you afraid he gets a Nobel, because the failed scientist in you hates the guts of successful ones? Well, if it works, he will indeed get a Nobel, a well deserved one, for pushing against the self-righteous that believe you are leading.
I will applaud. If he is wrong, I do not see much harm done, but history will judge, and you can be part of the trials, where you will get a chance to quench your appetite for blood and other bodily substances. Remember Carlos Lopez-Otin? Hydroxychloroquine can help to save lives. An European study is going to clarify that. Helen, maybe you should learn to read. I totally agree with Rd Lasius.
Read Leonid. Cultivate yourself a bit. In his work on bacteria, Raoult has successfully shown many times that the tree of life was a very poor model for reality that is much more bush-like. In fact, since Kimura, we know that Darwin initial guesses do not account very well for reality, especially the survival of the fittest paradigm. It is very clearly survival of the luckiest, which is not quite the same.
This is what Raoult says, in his flamboyant way, a bit exaggerated, but much more scientifically accurate that this poorly written blog implies. His theory has since then been corrected and enriched. Still now, many French people confuse Lamarckism with Darwinism and the present-day concepts of evolution.
Hello Ariane, I admire your eagerness to comment on a book you have not read … What Raoult is attacking is the cult-like status of Darwin, and the fact that Darwinism is too often hailed as religion. He is right. Raoult, as Popperian, claims his right to falsify Darwinism, as you would for any theory. You should go one day to one of his lectures.
On se concentre! Message you send with discrediting research effort during crisis like these could mean that you work for rich insurance funds who would rather have nothing used — and try to get rid of the old people…. If you are not — you should at least be aware of what damage you can provoke — just by having free time. Get in the hospital — and be useful. Actually I am on the payroll of Sanofi. OK, so with Trump apparently supporting Raoult, an army of volunteers have decided that scanning and running al the 3.
Here is what they came out with. This is what gets Leonid so excited. What drove me nuts these last years have been all the cases of bands flipped degrees — often out of the plane, something forbidden when ice skating — in photoshop and pasted. This is genuinely disingenuous. If it is a secondary supporting figure, you never catch it. Correcting the abstract is depressing enough…. Now, I would argue that with four exceptions, everything reported inpub-peerr is minor, and within the boundaries of acceptable mistakes in a very big lab.
Even considering the three worst ones band duplications and re-used background , If one was to randomly take 3. Because of Trump right? May the one who never messed up the images throw the first pixel. If you have no reason to fraud, the most likely explanation is a mistake. And yes, kit happens — A LOT. Bad style yes. Bad style, yes. AT the same time it is the validation of a monoclonal antibody. What an offense to science. Just a poor engineering paper.
Oh my god. Who has ever looked at S You put S15 for yourself, just to make sure you remember what you actually did. Retract Retract. Clinicians in Italy, Spain and France at this very moment are having to choose who to treat based on assumed outcome. Individuals requiring critical care will not receive it. Those individuals are entitled to that treatment and these states have an obligation to protect and care for its citizens. Unfortunately this pandemic has put clinicians in a war time situation and outcome based assessments are needed because of a lack of resources.
With the reality of having to deny individuals critical care and instead managing, if the patients are lucky, their final days and hours it would seem to me to be quite ethical for a doctor to consider a request from a patient for treatment with a combination of hydroxychloroquine and zpac. Difficulty to breathe? The same applies to the spindle poison colchicine, which also reduces inflammation by reduction of release of pro-inflammatory cytokines. Colchicine is concentrated in PMN and nerve cells, not in serum.
We have successfully used this — off label analog to Mediterranean familiar fever — to lower fever due to systemic IL-6 overproduction in a post- infectious syndrome of C jejuni, after prednisolone mg, novalgin mg , paracetamol mg , ibuprofen mg were ineffective in lowering fever.
However, this does not mean that HCQ interferes with the metabolism of Covid replication. These are eukaryotes, where it inhibits the ribosomal protein synthesis of prokaryotes bacteria that have been phagocytized. AZT could thus prevent bacterial superinfection as part of a Covid 19 virus infection. AZT is a macrolide, and an inhibitory intervention in Covid 19 virus replication would be extremely surprising. The combination of AZT and HCQ has also been successfully used to treat neuropsychiatric symptoms of a child, infected with B henselae, supra, unfortunately, the doctors had not carried out an analysis of the pro-inflammatory cytokines in that case.
So far, from clinical aspects, I would suggest, that the combination of HQC and AZT would simply ameliorate the inflammatory symptoms of Coronavirus infection, such as bacterial pneumonia, but not counter act the virus infection as such. So what you tell us is that all those searchers are fake and liars??
Interesting article that is so biased and full of attack. You should be a shame of yourself. We should have listened to the Chinese first, then to the Pr Raoult that basically run a study to verify these results and now backed up with another study on 80 patients and no confirmed by the Australian. This treatment is the only thing we have and if we had practiced it 2 months we would not have been where we are now. In time of urgency you have to take shortcut and trust your experts.
Let me guess you must be biased politically to write such crap. These experts dedicated their life to this science. Shame on you!!! While you eat your aquarium cleaner, I updated my article with this:. Pingback: De linke weekendbijlage - Kloptdatwel?
He just wants to promote his new book, issues yesterday, about pandemics how convenient …. As a non scientist, I have a couple of questions about modifying images in scientific publications. This was Anne Peyroche replying. Knowing her criminal energy, I would not trust the image she posted as raw data. Generally, raw, unadulterated data is prized. So the answer would be no. In any case, the target audience of scientific papers is scientific peers, not the public at large, so clarity is not often prioritised.
A certain mimimum level is required, but only in the sense that the arguments should be logical. In practice however, scientific papers are devoid of narrative, are often just listings of facts, and avoid saying one thing in more than one way, which is often a hallmark of clear exposition an exception would be summaries and abstracts, but these are meant to also be self-standing, that is why they repeat material.
Actually this is common in mathematical graphs, where axes and scales are often manipulated so that the figure will fit in its allocated space. Again however, the caption to the graph would really have to be explicit about what was done. I would say, it may diminish the respect and integrity attached to the authors, but may be not even in a substantial way, as long as, and this should be stressed, no intention to delude can be perceived.
However, deadlines, and the resulting rush often make it unclear as to what extent an image manipulation is an overt objective, rather than the effect of the pressure of having to submit within a prescribed time frame. Truly interesting content! I also feel very skeptical about chloroquine to treat Covid But some of your statements deeply question your own integrity and objectivity on this topic.
And strongly minors the credibility of this publication. Sorry about that. My apologies. I will delete my site now. Euh, no: French Government has not decided to deploy chloroquine as THE medecine to treat Covid19 : they just open the possibility to use it. As much as it pains you to give Dr. Raoult any credit, here are the results of a second study 80 patients that shows tremendous results.
Didier Raoult's follow up study on Hydroxycloroquine Azithromycin is still rigged. In addition to no control issue, Figure 1 re-creation turns out that the percentages are off. IrreproducibleFigure1 pic. Pingback: Thoughts on the Gautret et al. A new batch of datas has been send to the french experts by Raoult pertaining to more than patients contamined and treated with the 2 molecules. Only 1 death for the moment.
And how many of those patients were actually seriously ill? This is actually Raoult point. He give treatment as soon as you have symptoms or as you are test positive, so his method lower viral charge and lower chance to get more severed ill as he give medicin at the very early stage. Which he had and still has an excellent opportunity to do. FDA issues emergency authorization of anti-malaria drug for coronavirus care. Things were dire and working with doctors the police would take away sick family members to a field hospital.
This was done to help spare the rest of family and to help isolate the disease. My mother was 3 years old at the time with a baby sister. To avoid bringing the disease home, the doctor advised my grandfather to always wash up and change clothes outside the home.
In addition he was told to chew tobacco all day long. In the evening wash out the tobacco and gargle with scotch whiskey. The family stayed well through out the epidemic. At that time, there was no help at all, more worse, due to WW1, people, in particular of the loser-side Germany-Austria-Hungarian Nations on Balkan-Ukrainia were heavily starved and in addition incapacitated by tuberculosis, which paved the way for the viral invasion.
On other continents with different nutritional and infectious co-background , it could be different. You will see the study very soon. I do not know what you are talking about regarding spamming…. If the patient is seriously ill like intubeted the treatment wont work usually viral charge is low at that stage.
That is why Raoult recommands giving the treatment at the begining to reduce the viral charge so infection dont get time to develop. So i agree with a part of what you said treatement is not really working with patient seriously ill. The preprint was clear about the patients having tested positive for Covid but that does not generally result in hospitalization.
Most patients are just isolated at home and it is a pretty huge difference in severity between a mild fever to the need of intubation. Further, I see no justifications for not doing a proper randomized controlled trial with the patients who had mild symptoms. It seems to me that Raoult is so enamored with the idea of hydroxychloroquinine working that he is wasting precious time and resources that should have been used to test whether it actually works in a randomized trial.
The way it was done instead leaves me with absolutely no idea to whether hydroxychloroquinine really is working or not. COVID a tragedy that the humane among us will always remember, for reason of compassion. Raoult and Trump: men we will soon forget, for no worthy reason to remember them. My analysis is here. Figure 1: percentage was calculated as [N. This makes a little sense, because once result is negative, doctor is unlikely to order another test.
However, Figure 1 shows that ALL 80 patients were tested. This by Didier Raoult who originated the uncontrolled, poorly peer reviewed Hydroxycloroquine and Azithromycin study telling us that a control group in current study would violate the Hippocratic Oath. Nonsensical and irresponsible. However the report says, that best results are obtained with HCQ and AZT, if there is not yet fever, which means, that the alveolar-space, i.
That makes the difference in pathology, viremia, and therapeutic planning. Both substances have different pharmacokinetics in humans. Both substances are concentrated in the erythrocyte leucocytes? Published online Aug Free proportions of HCQ and CQ, volume of distribution and racemic concentrations are not comparable.
Lacking that information, it is very premature from a medical point of view to draw therapeutic end results for the medical treatment of COVID patients with HCQ, as reported by Professor D Raoult didier. On the other hand, one could regard this observational study as an important step further for elucidation a ratio of therapy of COVID Can you read beyond the heading? Do you know the difference between yourself and a dish of a cell culture monolayer? Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection.
In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds. Much in here is written to not even hide the BIAS dripping from it as if you wrote it in a fever pitch of Hate. Excellent article in the tradition of muck raking.
Keep up the good work. The hallmark of a dying and inquitous social arrangement is the inability to agree on the simplest of facts. Everybody is quick to call everybody a conman and slap a MeToo on it for good measure these days. Bu I am still undecided on the efficacy of HCQ.
This recent article argued that the dose of hydroxychloroquine required for clinically useful anti-COVID19 efficacy is below toxic levels. Raoult tried to have the most international research center and he welcomes students from various countries. But … because Prof Raoult is authoritarian, technical staff from IHU dedicated to research may fear to say that something is wrong or not working.
People were giving a 5 min —talk about their progress. This time was never a time for discussion between Prof Raoult and the presenters : people were just showing their slides in silence, Raoult was thinking , sometimes talking to one of the other professors. You have just to answer to specific questions and not invited to give any point of view.
When Raoult was not in a good mood, this staff meeting were like a roman circus game where people liked to see which one of their colleagues will be destroyed. The ones who did huges efforts to show nice work were preferentially targeted : Once, one of his recent co-author turned into red at the edge of crying while Raoult just denied his work in front of all the medical staff and crudely make fun of his work. I also saw two engineers crying when presenting their results until he suddenly stop their speech because they were not enought reactives to answer his questions.
His behaviour encouraged some of the technical staff of the IHU to hide negative results, or any problems concerning on-going experimentations. People used to discharge their failings to others so problems were never solved. And a simple mistake could become then a real problem. A lot of people had short-term contracts so they were hoping to get a permanent position and they were completely cared to loose their job.
So they were ready to do anything to stay in the institute. By the fact, some technicians and engineers are captivated by him and are mimicking him : bullying other staff especially those who have a fragile personnality. So when you know the context of the working environment at the IHU med Infection and you see that the published results have some biaises, you have to be cautious. This commentary is important, as much i like Raoult and his strong personality, as much it can be a double edge knife if his student and employees are scare of him..
I request all you learned people to finally get to the gist of the article and all the comments for scientifically illiterate people like me that in your learned opinion. Guys m not at all related to medical science m just a common citizen trying to find answers and positive news to further tell my kids and family.
All the hublabo about hydroxychloroquine gave us hope that all this might be over someday not too far. From what I understand that one cannot accept the snail paced highly meticulous approach of developing a cure when people are dying. What I want to know is did the treatment kill the virus in a lab. If it did then was it tried on patients, what was most of the outcome which side is the scale tilting. Then is it being used as a treatment at a larger scale? If yes then what do the results indicate is it working on most of the patients or not.
Why to complicate it so much. There are around half a million people infected so no death of subjects. If I was to get ill tomorrow I would want a treatment to be given to me which was working in most of the people. Also if roult is wrong what about anecdotal success stories coming across the world like that in india. Such fast most pandemic would require such fast moving research speed one cannot be taking thier own sweet time as if everything is normal and flowers are blooming and people are dancing.
Lastly why are the authorities not sharing the information on what is going on in the trials or what kind of results are being achieved with certain medicine as of now. So that people are well aware and also gain hope and positivity. In the end I apologize if I have said anything wrong or overstepped my bounds as I am an illiterate when it comes to science.
Were they cured, or did they simply get better like most corona patients do? As with any pneumonia, gentle but regular exercise is important. You are Indian, do Pranayama. They slowly drown. Fighting the infection is important. Finding stimulus to do so, outside os social means may difficult: you must look within. Gentle antiviral Sambuca and Amla which also stimulates the lungs are ancient ayurvedic remedies. They are accepted in Western medicine too. And are safe to use.
Some points to remember. Every SARS-COV2 infection is unique, because like other RNA viruses it mutates so fast that every codon in its genome will be changed many times in viruses within the resident population during the course of an infection. Every individual is unique in terms of their immune system, infection history, nutrition, health issues, etc. And societies differ greatly in the extent to which they can mobilize effective measures to prevent viral spread and care for those who become infected.
There will not be one solution to this problem, no matter how many snake oil salesmen roll into town trying to sell us one. A truly effective society would deal with these clowns in the time honored fashion, by tarring and feathering them and running them out of town on a rail.
Oder: Wie weit kann Euphorie gehen? Pingback: Sgamati! Tutto falso, ovunque! I am an environmental microbiologist native of Marseille where I did all my university studies. I am not particularly a fan of Prof. As a microbiologist, there is however a little point where I believe that you did nor report the correct information. In modern microbiology, no one will publish the description of a new genera or new species of bacteria that he isolated by giving himself his name to the new described mircroorganism.
If you take a look to the papers where Raoultella planticola and Rickettsia raoultii have been described, you will see that Prof Raoult was not an author of the articles:. Of course that some of the authors of these papers were closed collaborators of Prof. Raoult, but it is very common in bacteriology that new genera or species are named according to the name of researchers who made a great contribution to the field of microbiology and this of course is often done by past collaborators of these researchers.
Below some examples of this:. Methanospirillum hungatei named in honour of Prof. Robert Hungate Desulfomonile tiedjei named in honour of Prof. Gatze Lettinga Garciella nitratireducens named in honour to Dr. Jean-Louis Garcia etc, etc, etc. Then, by writing the text as you did, it seems that you want to give the feeling that Prof. Raoult has an oversized ego. You are maybe true, but the argument that you used here is not valid. As a consequence, I believe that you should rephrase this sentence or eliminate it from your article.
Thanks for sharing this. However, the authors of both papers are based in Marseille. I will adjust the sentence acocordingly. Raoult is proven correct, will you admit he was right and you were wrong, or will you ignore the truth because you dont like the way they got there? The old saying is that a broken clock is right twice a day, or perhaps more appropriate in this case, even a blind pig finds the odd truffle.
I can see that for whatever the political reasons may be, the so-called advanced nations that have allowed their biomedical science systems to become dominated by half-bright wankers — many featured in this blog — are showing strikingly high rates of infection, and shockingly high death rates from same. Pretending to be a proper scientist is about the most bourgeois thing I can think of — aside from considering the ethical testing of treatments to be sociopathic.
You have not even read the headlines behind the links you shared. This means: it contains NO new research, but discusses the work by Raoult and others. Do you understand what this means to your argument? Probably not. You are not a doctor, right? Not even working in medical profession, just another tech aficionado who thinks he is the expert in medical research. Here, you like to pretend that you are saving human lives daily, while the rest of us are just writing academic treatises for the purpose of self-promotion.
Just like Prof Raoult does, every day another paper. Oh wait. Good bye. Concurrent sociopathic attitudes can be remedied by waiting 2 years, possibly in expedited fashion. Ideally results in the perfect test. First author here. I apologize for the mistakes which seem to have sneaked in during manuscript preparation. Raoult had and still has a large number of mild cases that could easily have been randomized properly. If we disregard that he seems quite untrustworthy, we would have had the results from the same patients by now and got a much better view of whether the treatment is helpful or not.
If HCQ later turns out to be helpful, the credit is to be given to serious researchers who investigated it properly in random controlled studies rather than to snake oil salesmen like Raoult. Dear Leonid Schneider, Not only French, but other eminent European scietist like Elena Gomez and science influencer elenagomezdiaz , support the use of hidroxicloroquine. Leonid Schneider is the one that is wrong again. Thanks Leonid.
But I think you misunderstood me. Pingback: Fake vaccine research: new low for science fraud — For Better Science. Pingback: Drs. Pingback: Updates — House of Dog. Pingback: Quote du Jour Chloroquine een wondermiddel? Does it work? I see a small flawed study or now 2 by a man who should know better. Miraculously, the results of this study reach the most powerful man in the world almost instantaneously. Raoult fired the gun. Rupert Murdoch is a pro-vaxxer.
Doing good work in Australia Could it be the influence of his humanitarian wife? Or is it his tight connection to Sanofi- the French Vaccine and Hydroxychloroquine manufacturers? Meanwhile in America The followers of President Trumpers are predominately anti-vaxx.
Now in France, a researcher-for-hire publishes a lame pro Hydroxychloroquine paper. Immediately Fox picks it up. If the well-respected researcher is correct, Trump will have captured the glory. For the world, for science, there is short term damage- other drugs may not be tested as quickly as they might otherwise-. The motives are that Didier wants more fame and Trump needs to show an effective treatment in order to convince people not to worry about it.
No one will care anymore whether the treatment he proposed was actually effective because a lot of the public now believes it is. Nobody owns hydroxychloroquine, it is long out of patent. India makes tons of it for malaria prophylaxis, which is why DJT tried to strong-arm his bhai Modi into parting with a few million tabs. The problem here is less one of profiteering than of pushing a dubious treatment.
This is something. Then this must be done! Pingback: Toi aussi comprends le professeur Raoult version avec sous-titres — Flint Times. Shame to the author. I beg your pardon? How can one spread such a stereotype? Yes, there are arseholes here too. There are arseholes everywhere. Strangely enough chloroquine had previously been an over the counter drug for decades and billions of people have taken it at length.
Professor Raoult has been working on hydroxychloroquine for 13 years and has published extensive papers on its use that are easy to find. And for this matter, I would like to signal that professor Raoult has received insulting emails and death threats on his phone from a doctor in Nantes who has interests in the pharmaceutical industry too he was naive enough to use his personal phone to send the messages. Some new bugs bear his name, he has published more than papers over the course of a 43 year old carrier while still working at the hospital one day a week to stay in touch with true medical practice with patients.
He calls himself a doctor and says that as a doctor his role is to treat patients as efficiently and fast as possible to save their life. There was especially a duplex with a professor in Marseille, a polite, kind and gentle man, explaining the results and the practice and doctors and journalists in Paris so rude, literally talking to each other and making comments about him aloud while he was trying to explain how they worked and what the results were.
The French government has allowed chloroquine only in hospital and on dying patients, knowing perfectly well that it has at this stage become totally useless, so that they can say there were patients dying on hydroxychloroquine. I wanted to ad that after all the prizes he has already received for his discoveries on new bugs, and before his fight for the use of the two medicines professor Raoult had good chances to be awarded a Nobel Prize but now he has no chance at all, which I personally find rather brave on his part.
It is very unfortunate that your president trump has tweeted positive stuff about the two remedies. If today a member of your family was suffering from covid 19 would you give them 2 of the currently most common medicines in the world or would you rather wait until a randomised study had been extensively done?
And if your parent was in the study would accept the risk that they be given the placebo medicine? Most of the general practioners knows that such medicines like oseltamivir or aciclovir act only when used as soon as possible. Is it the time to turn on the drugs not crucial?
Pingback: Dr. THis article is another obviously biased hatchet-job on a scientist because he has spoken out about the global fascist buffoonery that is the climate change hoax. The author of this article is a fraud. Anyone who says hydroxychloroquine is not efficacious is just flat lying. And Covid represents literally the biggest big-pharma profit opportunity ever on earth, if they can discredit the cheap and effective alternatives and steer you to something patented — for which they can name any price, and the world will pay it.
Predictive success is the hallmark of science as opposed to pseudo-science. Once Trump touted it there was no question in my mind the drug was as big a fraud as the Orange Caligula himself. Looks like Big Pharma and the Trump haters got to them too….
Pingback: Hydroxychloroquine and the price of abandoning of science- and evidence-based medicine — Science-Based Medicine. Pingback: They attack in the same way; they affect people in the same way. Are you going to deny the doctor here in the US that has treated over patients successfully?
It should be noted that if you start treatment too late, people are going to die. Treatment must be started ASAP to be effective. From Biochem Biophys Res Commun. Published online Sep Time-of-addition experiments indicated that chloroquine affected an early stage of SARS coronavirus replication. If animal models confirm these results, chloroquine might represent a valuable therapeutic option if SARS re-emerges.
The broad spectrum antiviral effects of chloroquine deserve particular attention in a time in which the world is threatened by the possibility of a new influenza pandemic, and the availability of effective drugs would be fundamental during evaluation of an effective vaccine. The effect of chloroquine against replication of Orthomyxoviridae has long been known.
If these effects are confirmed, chloroquine would deserve to be tested against the H5N1 type A avian influenza virus, currently a matter of serious concern for public health. As discussed above, glycosylation inhibition might represent a major mechanism for the antiviral effects of chloroquine, suggesting that specific interactions of chloroquine with sugar-modifying enzymes or glycosyltransferases may occur within human cells figure.
Chloroquine was recently shown to inhibit quinone reductase 2,13 a structural neighbour of UDP-N-acetylglucosamine 2-epimerases,14 which are involved in sialic acid biosynthesis. If chloroquine should indeed inhibit the biosynthesis of sialic acid, this effect could explain not only the effects of chloroquine on HIV and SARS coronavirus sialic acid moieties are present in HIV-1 glycoproteins and SARS coronavirus receptor ACE2 , but also the in-vitro effects on orthomyxoviruses which use sialic acid moieties as receptors These effects deserve further investigation, in that they may lead to new strategies controlling the replication of several viruses.
However, in-vitro is a good base for further in-vivo studies. Thank you for your post. To them, the more people that die fits their globalism depopulation goals. Why you ask would he support this drug? We should be following the advice of Dr. Didier Raoult, Dr.
They want you to live in fear under their control; period. That constitutes a new low in pseudoargumentation. As I mentioned earlier, this is a good representation of the dark side of American culture…. This of course is irresponsible, deliberate malpractice. Doctors who use it know it must be used in combination with Zinc and Azithromycin or other drugs to work as a treatment.
There is finally a study, peer reviewed and passed, to show that Dr. Only one person died in this study. I personally consider refusing to use a treatment that is readily available for an at risk patient to be nothing less than murder. Pouvez-vous me donner votre avis? How did this buffoonish fraud ever get to be so influential in France in the first place?
Pingback: Didier Raoult: Fin de Partie? What about a new update to your compilation on their stat. Pingback: Predatory journal accepts fake story about scooters and hydroxychloroquine — Science Integrity Digest. Update from France. Raoult is trying to come back into the limelight claiming that COVID infected people die comparatively less in Marseilles than anywhere else in France or Paris.
But even the French news channel BFM TV on which he add the opportunity to express his views so many times seems to be interested in distancing itself from him. Pour les militants anti-HCQ, une seule solution : kill the messenger. Pingback: Colchicine or Liquorice? You are commenting using your WordPress. You are commenting using your Google account. You are commenting using your Twitter account.
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If he was in a bad mood, he could completely destroy the student in front of every one — Donyk BDonyk March 26, Share this: Tweet. Like this: Like Loading March 26, Nano Letters , 18 11 , Ortega, Fabiano G. Langmuir , 34 4 , Whang , and Chinedum O. Langmuir , 33 40 , Langmuir , 30 50 , Carbocatalysis by Graphene-Based Materials. Chemical Reviews , 12 , Low hysteresis relative humidity sensing characteristics of graphene oxide—gold nanocomposite coated langasite crystal microbalance.
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International Journal of Pharmaceutics , , Synergistic modification by mercapto hyperbranched polysiloxane and functionalized graphene oxide on the surface of aramid fiber. Polymer Testing , 91 , Tu , Huong T. Nguyen , Dao T. Phan , Van Chinh Hoang. One-step and surfactant-less synthesis of highly dispersed Ag nanoparticles on graphene oxide as highly effective catalyst for removal of organic dyes. Synthetic Metals , , Nanomaterials , 10 11 , Oliva , J.
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Journal of Materials Science , 55 5 , Binder-free ultra-thin graphene oxide as an artificial solid electrolyte interphase for anode-free rechargeable lithium metal batteries. Journal of Power Sources , , Application of modified graphene oxide — Polycaprolactone nanocomposite coating for corrosion control of mild steel in saline medium. Materials Chemistry and Physics , , Measuring the specific surface area of monolayer graphene oxide in water.
Materials Letters , , A review on application of carbon nanostructures as nanofiller in corrosion-resistant organic coatings. Journal of Coatings Technology and Research , 17 1 , Carrasco , Eugenio Coronado. Layered double hydroxide nanocomposites based on carbon nanoforms. Layered Double Hydroxide Polymer Nanocomposites. Nanoengineering in the Beverage Industry.
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